GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs7760207 | chr6:86721700 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -9.4 | 5.22E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs9910950 | 1 | rs77620153 | chr17:64130794 | AXIN2 | chr17:63524685-63637183:- | 0.56 | 4.89 | 1.5E-6 | Presence of antiphospholipid antibodies |
| BLCA | cis | rs1577917 | 1 | rs7766645 | chr6:86622238 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10.06 | 2.88E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs7714584 | 1 | rs77698001 | chr5:150250367 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.86 | 1.0E-8 | Crohn's disease |
| BLCA | cis | rs6951245 | 1 | rs77702926 | chr7:1088838 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.9E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs1577917 | 1 | rs7771342 | chr6:86631936 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -9 | 1.03E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs9369898 | 1 | rs7774688 | chr6:49387292 | CENPQ | chr6:49431096-49460820:+ | -0.4 | -8.67 | 1.24E-16 | Homocysteine levels |
| BLCA | cis | rs6951245 | 1 | rs77760339 | chr7:1083927 | ZFAND2A | chr7:1192544-1199855:- | -0.39 | -4.55 | 7.23E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs886774 | 1 | rs7776797 | chr7:107493598 | DLD | chr7:107531586-107561642:+ | 0.22 | 4.06 | 5.97E-5 | Ulcerative colitis |
| BLCA | cis | rs11976180 | 1 | rs7777389 | chr7:143744802 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.92 | 7.15E-9 | Obesity-related traits |
| BLCA | cis | rs2243480 | 1 | rs7778911 | chr7:65694506 | CCT6P1 | chr7:65216092-65228661:+ | -0.33 | -4.52 | 8.25E-6 | Diabetic kidney disease |
| BLCA | cis | rs2285947 | 1 | rs7781669 | chr7:21584820 | DNAH11 | chr7:21582833-21941455:+ | -0.31 | -5.04 | 7.07E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs2243480 | 1 | rs778679 | chr7:65840911 | CCT6P1 | chr7:65216092-65228661:+ | 0.37 | 4.94 | 1.2E-6 | Diabetic kidney disease |
| BLCA | cis | rs6951245 | 1 | rs77868187 | chr7:1093968 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.32E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2243480 | 1 | rs778691 | chr7:65873092 | CCT6P1 | chr7:65216092-65228661:+ | 0.37 | 4.98 | 9.6E-7 | Diabetic kidney disease |